HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2',3'-Didehydro-3'-deoxy-4-thiothymidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 86749325 | HCID 86749325 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2',3'-Didehydro-3'-deoxy-4-thiothymidine | HCID 3000238 | — |
Reaction Steps
To 100 mg of the compound synthesized in Example 9, 10 mL of methanol are added, which had been saturated at 0° C. with ammonia. The reaction mixture is kept for 12 hours at room temperature and then evaporated to dryness. Crystals, melting at 117° C.-118° C., are obtained from methanol/ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05496935 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-71df7d1b7df54b8baf4c1471c31c5f27 |
| Source note | uspto-grants-1996_03 |