Salicylaldehyde → HCID 86749326, compound

Participants

Reaction Steps

To a mixture consisting of 15.5 g L-histidine, 15.1 g L-(+)-tartaric acid was added 85 ml of the recovered acetic acid solution containing salicylaldehyde from the previous experiment. Additional 10 ml acetic acid containing 0.54 ml salicylaldehyde was added, and the mixture was stirred and heated as above at 80°-100° C. for two hours. After cooling to 25° C. the crude product D-His-(+)TA was filtered. 79 ml of acetic acid containing salicylaldehyde was recovered (83.2%). After stirring in hot water as above, pure D-His-(+)TA was obtained, 25.9 g (85% yield from L-His).

Provenance & Evidence