HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ramosetron Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ramosetron | HCID 108000 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | Ramosetron Hydrochloride | HCID 107999 | — |
Reaction Steps
In ethanol/ethyl acetate was dissolved 100 mg of (R)-(-)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole obtained in Example 43(b), and a solution of hydrogen chloride in ethyl acetate was added thereto. The thus formed crystal was collected and recrystallized from ethanol to obtain 70 mg of (R)-(-)-5-[(1-methylindol-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05496942 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-8aff030058fb41aeb9c27cefb453352f |
| Source note | uspto-grants-1996_03 |