HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylalanine ethyl ester → (+/-)-N-[2-(acetylthiomethyl)-4-methyl-1-oxopentyl]-L-phenylalanine, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylalanine ethyl ester | HCID 76506 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-[(Acetylthio)methyl]-4-methylpentanoyl chloride | HCID 12769074 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (+/-)-N-[2-(acetylthiomethyl)-4-methyl-1-oxopentyl]-L-phenylalanine, ethyl ester | HCID 131719290 | — |
Reaction Steps
2-Acetylthiomethyl-4-methylpentanoyl chloride and (L)-phenylalanine, ethyl ester are reacted in methylene chloride in the presence of diisopropylethylamine at a temperature below 0° according to the procedure of Example 26 to yield (±)-N-[2-(acetylthiomethyl)-4-methyl-1-oxopentyl]-L-phenylalanine, ethyl ester as an off-white foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05496805 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-8ea3a47c04da488ebb8bb1a1a7a082df |
| Source note | uspto-grants-1996_03 |