HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → (+/-)-8-[[2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]amino]octanoic acid, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-[(Acetylthio)methyl]-3-phenylpropionic Acid | HCID 9991796 | — |
| Reactant | Methyl 8-aminooctanoate hydrochloride | HCID 12878164 | — |
| Product | (+/-)-8-[[2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]amino]octanoic acid, methyl ester | HCID 14155014 | — |
Reaction Steps
2-Acetylthiomethyl-3-phenylpropanoic acid is reacted with oxalyl chloride and the resulting acid chloride is then reacted with 8-aminooctanoic acid, methyl ester hydrochloride in the presence of diisopropylethylamine as more fully described in Example 11 of European Patent Application 136,883 to give (±)-8-[[2-[(acetylthio)methyl]-1-oxo-3phenylpropyl]amino]octanoic acid, methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05496805 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-eb3592faf72240fa98a5113c44381ecc |
| Source note | uspto-grants-1996_03 |