HCID 12769077, compound → HCID 178477071, compound

Participants

Reaction Steps

As described in Example 7 of U.S. Pat. No. 4,235,885, this compound can be prepared by reacting (±)-N-[2-[(acetylthio)methyl]-4-methyl-1-oxopentyl]glycine, 4-nitrophenyl ester with (L)-arginine to give (±)-N-[N-[2-[(acetylthio)methyl]-4-methyl-1-oxopentyl]glycyl]-L-arginine. An aqueous chilled solution of this product is then treated with concentrated ammonia to give (±)-N-[N-[2-(mercaptomethyl)-4-methyl-1-oxopentyl]glycyl]-L-arginine; m.p. 132°-146°.

Provenance & Evidence