Dibenzyl (2-phenylethyl)phosphonate → HCID 131719292, compound

HRID 1440084Notes

Reaction equation

HRID 1440084 reaction equation
[C:1]1([CH2:7][CH2:8][P:9](=O)([O:18]CC2C=CC=CC=2)[O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:27][C@@H:28]([CH2:47][C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1)[C:29]([NH:31][C@H:32]([C:37]([O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)=[O:38])[CH2:33][CH:34]([CH3:36])[CH3:35])=[O:30]>>[C:12]1([CH2:11][O:10][P:9]([CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)([O:27][C@@H:28]([CH2:47][C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[C:29]([NH:31][C@H:32]([C:37]([O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)=[O:38])[CH2:33][CH:34]([CH3:36])[CH3:35])=[O:30])=[O:18])[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 13630870Dibenzyl (2-phenylethyl)phosphonateHCID 131719293HCID 131719293, compound

Product 1

HCID 131719292HCID 131719292, compound

Procedure

This (2-phenylethyl)phosphonic acid, dibenzyl ester is reacted with N-[(S)-2-hydroxy-3-phenyl-1-oxopropyl]-L-leucine, phenylmethyl ester according to the procedure described in Example 76 to give N-[(S)-2[[(phenylmethoxy)(2-phenylethyl)phosphinyl]oxy]-1-oxo-3-phenylpropyl]-L-leucine, phenylmethyl ester as a colorless oil.

Sources & evidence

ORD record
ord-c20e38f4a3734a818b3f5efcd754ec63
Source dataset
uspto-grants-1996_03
Patent number
US05496805

Reaction notes

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