反应详情

A solution of 22.20 g (0.3 mole) of epifluorohydrin and 67.95 g (0.45 mole) of N-benzylethanolamine dissolved in 200 ml of ethanol was heated under reflux for 5 hours. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and the residue was purified by column chromatography through silica gel using ethyl acetate as the eluent, to give 64.93 g of N-benzyl-N-(3-fluoro-2-hydroxypropyl)ethanolamine as a colorless oil.

1. temperaturewas heated
2. temperatureunder reflux for 5 hours
3. concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
4. customthe residue was purified by column chromatography through silica gel