反应详情

温度

100 °C

34.5 g of 1-(2,5-difluorophenyl)-3-(trifluoromethyl)-propane-1,3-dione was dissolved in 250 ml of acetic acid and 9.5 mL of methylhydrazine slowly added. The mixture was heated at 100° C. for 5 minutes then cooled and diluted with ether. The ether solution was washed with water and potassium carbonate solution, then dried with magnesium sulfate, filtered and concentrated. The residue was chromatographed to give 9.5 g of 3-(2,5-difluorophenyl)-1-methyl-5(trifluoro-methyl)-1H-pyrazole.

1. temperaturethen cooled
2. washThe ether solution was washed with water and potassium carbonate solution
3. dry with materialdried with magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was chromatographed