Sodium Methoxide → HCID 14659592, compound

Participants

Reaction Conditions

Reaction Steps

Compound (2) (9.13 g) was dissolved in methanol (100 ml). To this solution, sodium methoxide was added at 0° C. until the pH became almost 12, followed by stirring at 0° C. for 1 hour. After completion of the reaction, the solution was neutralized with ion exchange resin Amberlite IR-120 (H+). The resin was filtered out and washed with methanol. The filtrate was combined with washings, followed by concentration under reduced pressure. The resulting residue was subjected to column chromatography (Wako Gel C-200, dichloromethane/methanol=50/1 ) to yield compound (3) (4.96 g, 85.1%).

Provenance & Evidence