Sodium Hydroxide → HCID 18982861, compound

Participants

Reaction Steps

In 50 ml of tetrahydrofuran was dissolved 4.0 g of 6-(1-acetoxyethyl)-4,5-dichloropyrimidine, and 30 ml of a 1N-sodium hydroxide aqueous solution was slowly added dropwise to the solution under stirring. After the dropwise addition, the mixture was further stirred at room temperature for 1 hour to complete the reaction. Then, the reaction mixture was extracted with ethyl acetate, washed with water and dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The resulting oily product was purified by silica gel column chromatography (Wako gel C-200 (trade name, manufactured by Wako Junyaku Co.), eluted by toluene:ethyl acetate=5:1) to obtain 2.8 g of the title compound as a pale yellow liquid.

Provenance & Evidence