N-[1-(phenylmethyl)4-methyl-4-piperidinyl]acetamide hydrochloride → 155928-36-2

HRID 1440214Notes

Reaction equation

HRID 1440214 reaction equation
[ClH:1].C1(C[N:9]2[CH2:14][CH2:13][C:12]([NH:16][C:17](=[O:19])[CH3:18])([CH3:15])[CH2:11][CH2:10]2)C=CC=CC=1.[H][H]>CO.[Pd]>[ClH:1].[CH3:15][C:12]1([NH:16][C:17](=[O:19])[CH3:18])[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

Participants

5

Reactant 2

HCID 21472468N-[1-(phenylmethyl)4-methyl-4-piperidinyl]acetamide hydrochlorideHCID 178418361HCID 178418361, compound

Product 1

HCID 21472474155928-36-2Yield 91.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 19 g of N-[1-(phenylmethyl)-4-methyl-4-piperidinyl]acetamide hydrochloride in 400 ml of methanol was hydrogenated at normal pressure and at room temperature with 5 g of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 11.8 g of N-[4-methyl-4-piperidinyl]acetamide hydrochloride; mp. 230°-233° C. (interm. 3).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-6c60bffb7fa345459af82459c868f700
Source dataset
uspto-grants-1996_03
Patent number
US05498618

Reaction notes

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