Thionyl Chloride → HCID 19973449, compound

HRID 1440244Notes

Reaction equation

HRID 1440244 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[CH:6][N:5]2[CH:12]=1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:15][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:12]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19973434HCID 19973434, compound

Product 1

HCID 19973449HCID 19973449, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

6.80 g of the 2-methylimidazo[1,2-a]pyridine-6-methanol prepared in the Preparative Example 16 was dissolved in 90 ml of chloroform, followed by the dropwise addition of 6.1 ml of thionyl chloride under stirring at room temperature. After 2 hours, the solvent was distilled off. Crude 6-chloromethyl-2-methylimidazo-[1,2-a]pyridine hydrochloride was obtained as a brown oil.

Workup

  1. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-ac7b6567428d4b3d9a3f0e2f323b612b
Source dataset
uspto-grants-1996_03
Patent number
US05498634

Reaction notes

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