反应详情

温度

25 °C

A mixture of N-benzyloxycarbonyl-O-methyl-isourea (II-OMe) (0.42 g, 2.0 mmol) and 1,2-diaminoethane (Ic) (0.72 g, 12 mmol) was stirred at 40° C. for 3 h and at 25° C. for 1 h. The crystals were collected by filtration. The white crystalline product was washed with toluene (4×1 mL) and dried (vacuum, 30°-35° C., 2 h). The yield of N-(2-aminoethyl)-N'-benzyloxycarbonyl guanidine IlIc was 0.28 g (60% in theory).

1. filtrationThe crystals were collected by filtration
2. washThe white crystalline product was washed with toluene (4×1 mL)
3. customdried (vacuum, 30°-35° C., 2 h)