Tetrahydrofuran → HCID 178460948, compound

Participants

Reaction Steps

4.8 g (20 mmol) of p-trifluoromethoxybromobenzene was dripped into a mixture of 0.5 g (21 mmol) of magnesium and 50 ml of THF to obtain a Grignard's reagent. This solution was then dripped into a 50 ml THF solution of 10 mg of copper chloride (I), 10 mg of copper chloride (II) and 7.3 g (20 mmol) of trans-4-(2-bromoethyl) cyclohexyl)-1-n-propyl-1-silacyclohexane. After a conventional after treatment, 6.6 g (yield 80%) of trans-4-(trans-4-(2-(4-trifluoromethoxyphenyl) ethyl) cyclohexyl)-1-n-propyl-1-silacyclohexane was obtained.

Provenance & Evidence