HCID 178505680, compound → HCID 178447770, compound

Participants

Reaction Steps

3.0 g (20 mmol) of 3-methylbutyl bromide was dripped into a mixture of 0. 5 g (21 mmol) of magnesium and 50 ml of THF to obtain a Grignard's reagent. This solution was then dripped into a 50 ml THF solution of 7.1 g of 1-chloro-4-(trans-4-(2-(3,4-difluorophenyl) ethyl) cyclohexyl)-1-silacyclohexane. The silacyclohexane rings of the reacted mixture thus obtained were a mixture of trans isomers and cis isomers. After a conventional after treatment, they were separated by means of chromatography to obtain 6.9 g (yield 88%) of trans-4-(trans-4-(2-(3,4-difluorophenyl) ethyl) cyclohexyl)-1-(3-methylbutyl)-1-silacyclohexane.

Provenance & Evidence