Ammonia → HCID 178437557, compound

HRID 1440394Notes

Reaction equation

HRID 1440394 reaction equation
N.[Br:2][C:3]1[C:7]2[CH:8]=[C:9]([CH2:12][N:13]3[C:17]([C:18]([NH2:20])=[O:19])=[C:16]([CH:21]4[CH2:23][CH2:22]4)[N:15]=[C:14]3[CH2:24][CH3:25])[CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[NH:32][S:33]([C:36]([F:39])([F:38])[F:37])(=[O:35])=[O:34]>C(O)C>[NH4+:13].[Br:2][C:3]1[C:7]2[CH:8]=[C:9]([CH2:12][N:13]3[C:17]([C:18]([NH-:20])=[O:19])=[C:16]([CH:21]4[CH2:22][CH2:23]4)[N:15]=[C:14]3[CH2:24][CH3:25])[CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[NH:32][S:33]([C:36]([F:39])([F:37])[F:38])(=[O:35])=[O:34]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 60921Saprisartan

Product 1

HCID 178437557HCID 178437557, compoundYield 194.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated aqueous ammonia (0.2 ml) was added to a solution of the product of Example 6 (50 mg) in ethanol (1 ml) at room temperature. The mixture was stirred for 30 min, then the solvent was evaporated. The residue was triturated under ether (2 ml) and filtered to give the title compound as a colourless solid (50 mg), m.p. 135°-142°.

Workup

  1. customthe solvent was evaporated
  2. customThe residue was triturated under ether (2 ml)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-1e5f5913a4fb45718c3efac510c9a313
Source dataset
uspto-grants-1996_03
Patent number
US05498722

Reaction notes

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