HCID 18983607, compound → HCID 15479546, compound

Participants

Reaction Steps

N-Isopropyl 4,4,-dimethyl-2-oxo-6-nitroquinoline (Compound 40, 220 mg, 0.84 mmol) was dissolved in CH3OH (3 ml). The solution was cleansed by flushing with N2 gas, and thereafter a catalytic amount of 10% Pd/C was added. The resulting mixture was hydrogenated at room temperature for 5 hours. After evaporation of the solvent the title compound was obtained in quantitative yield as a light purple oil. (184.2 mg 94%) 1H NMR d 1.23 (s, 6H), 1.49 (d, J=7.0 Hz, 6H), 2.36 (s, 2H), 4.68 (q, J=7.0 Hz, 1H), 6.55 (dd, J1=2.8 Hz, J2 =8.6 Hz, 1H), 6.64 (d, J=2.6 Hz, 1H), 6.94 (d, J=8.6 Hz, 1H).

Provenance & Evidence