Tetrahydrofuran → HCID 54530116, compound

Participants

Reaction Conditions

Reaction Steps

Into a 200-ml flask equipped with a stirrer and a condenser were charged 8.0 g of 3-(p-hydroxyphenylthio)propanamide, 10.6 g of N-hydroxymethyl-n-octadecanamide, 5 drops of concentrated hydrochloric acid and 120 ml of tetrahydrofuran, and stirred with heating at 60° C. for 5 hours. The reaction mixture was cooled to room temperature and then poured into 300 ml of distilled water. The white crystals precipitated were collected by filtration and recrystallized from isopropanol to obtain 12.0 g of the desired compound. Melting point: 172° C.

Provenance & Evidence