Nitric Acid → HCID 18630145, compound

HRID 1440593Notes

Reaction equation

HRID 1440593 reaction equation
[CH2:1]([NH:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:2].[N+:16]([O-])([OH:18])=[O:17].S(=O)(=O)(O)O>C(Cl)Cl>[CH2:1]([NH:3][C:4](=[O:15])[C:5]1[CH:10]=[C:9]([N+:16]([O-:18])=[O:17])[CH:8]=[CH:7][C:6]=1[Si:11]([CH3:14])([CH3:13])[CH3:12])[CH3:2]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 18630201HCID 18630201, compound

Product 1

HCID 18630145HCID 18630145, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of the amide of example 49 (1.10 g, mmol) in CH2Cl2 (50 mL) at 0° C. was added dropwise over 2 min, a cold mixture of 70% nitric acid (0.95 mL, 15 mmol) and concentrated sulfuric acid (5 mL) dropwise. The mixture was stirred at 0° C. for 10 min and was poured onto ice. The mixture was extracted with ethyl acetate, the combined organic layers washed with brine, sat NaHCO3, brine, dried (MgSO4) and concentrated to a solid (2.68 g, 101%) consisting of a 2:1 ratio of 5-nitro and 3-nitro isomers. The title compound was obtained by RC (ethyl acetate/hexanes) in 60% yield as a white solid. m.p. 100°-102° C.

Workup

  1. additionwas poured onto ice
  2. extractionThe mixture was extracted with ethyl acetate
  3. washthe combined organic layers washed with brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated to a solid (2.68 g, 101%)

Sources & evidence

ORD record
ord-b45703a20f024f4284d703e89ef09fbb
Source dataset
uspto-grants-1996_03
Patent number
US05498630

Reaction notes

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