Ammonia → HCID 15023182, compound

HRID 1440650Notes

Reaction equation

HRID 1440650 reaction equation
Cl[C:2]1[C:6]([C:7]2[C:12]([Cl:13])=[CH:11][CH:10]=[CH:9][C:8]=2[Cl:14])=[N:5][S:4][N:3]=1.[NH3:15]>CO.[Cu]>[NH2:15][C:2]1[C:6]([C:7]2[C:12]([Cl:13])=[CH:11][CH:10]=[CH:9][C:8]=2[Cl:14])=[N:5][S:4][N:3]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 10264857HCID 10264857, compound

Product 1

HCID 15023182HCID 15023182, compound

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 887MethanolSolvent

Conditions

Temperature
120 °C

Procedure

A solution in methanol containing 5.31 g of 3-chloro-4-(2,6-dichlorophenyl)-1,2,5-thiadiazole, 1.91 g of copper powder and 1.97 g of cuprous chloride saturated with ammonia gas was placed in a stainless steel vessel. After sealing the vessel, the solution was stirred at 120° C. for 24 hours. After allowing the mixture to cool, insoluble materials were removed by filtration. The filtrate was concentrated and the residue was purified by silica gel column chromatography to obtain 2.19 g of 3-amino-4-(2,6-dichlorophenyl)-1,2,5-thiadiazole.

Workup

  1. temperatureto cool
  2. custominsoluble materials were removed by filtration
  3. concentrationThe filtrate was concentrated
  4. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-ded6fa1ff8664952849d39e6facf93b0
Source dataset
uspto-grants-1996_03
Patent number
US05500408

Reaction notes

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