HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenol → 58651-76-6
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | S-(acetamidomethyl)-N-(tert-butoxycarbonyl)-L-cysteine | HCID 88223 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 58651-76-6 | HCID 12932263 | 81% |
Reaction Steps
BocCys(Acm)ONp is prepared from BocCys(Acm)OH (Novabiochem, Laufelingen, CH) and p-nitrophenol by reaction with N,N'-dicyclohexylcarbodiimide (DCC) in etyl acetate and used without purification for the preparation of Boc-Cys(Acm)-Pro-OH (XII) by reacting it with H-Pro-OH in DMF/etyl acetate/H2O at 0° C. while keeping pH neutral by addition of Et3N. Yield 81%. Purity>95% (TLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05500413 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-88ec551267e14a9ab25c5e829cd4a6ba |
| Source note | uspto-grants-1996_03 |