HCID 10825133, compound → HCID 10559045, compound

HRID 1440755Notes

Reaction equation

HRID 1440755 reaction equation
[CH3:1][N:2]([CH2:10][CH2:11][NH:12][CH:13]([CH:17]1[CH2:19][CH2:18]1)[CH:14]1[CH2:16][CH2:15]1)CC1C=CC=CC=1>C(O)C.[Pd]>[CH3:1][NH:2][CH2:10][CH2:11][NH:12][CH:13]([CH:17]1[CH2:19][CH2:18]1)[CH:14]1[CH2:15][CH2:16]1

Participants

4

Reactant 1

HCID 10825133HCID 10825133, compound

Product 1

HCID 10559045HCID 10559045, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
45 °C

Procedure

5.8 g of the compound obtained in Step b, in 30 ml of absolute ethanol, and 100 mg of 10% palladium-on-carbon are stirred and heated at 45° C. under a hydrogen atmosphere for 3 hours. The solvent is evaporated off. After customary treatment of the organic phase, the desired crude product is purified by distillation.

Workup

  1. customThe solvent is evaporated off
  2. distillationAfter customary treatment of the organic phase, the desired crude product is purified by distillation

Sources & evidence

ORD record
ord-73ac7562358b4e479ed2e4a85b5f6d0e
Source dataset
uspto-grants-1996_03
Patent number
US05500426

Reaction notes

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