4,6-Pyrimidinediamine, 2-(methylthio)-5-nitroso- → HCID 178503367, compound

HRID 1440885Notes

Reaction equation

HRID 1440885 reaction equation
[NH2:1][C:2]1[C:7]([N:8]=O)=[C:6]([NH2:10])[N:5]=[C:4]([S:11][CH3:12])[N:3]=1.NC1C(N=O)=C(N)N=C(NCCC2C=CC=CC=2)N=1.NC1C(N=O)=C(N)N=C(NCCC2[CH:50]=[CH:49][C:48]([O:51][CH3:52])=[C:47](OC)C=2)N=1.NC1C(N=O)=C(N)N=C(NCCC2C=CC(OC)=CC=2)N=1.C1(CCNC2N=C(N)C(N)=C(N)N=2)C=CC=CC=1.COC1C=C(CCNC2N=C(N)C(N)=C(N)N=2)C=CC=1OC.CC1C=CC(CCNC2N=C(N)C(N)=C(N)N=2)=CC=1>>[NH2:1][C:2]1[NH:3][C:4]([S:11][CH3:12])=[N:5][C:6]2[C:7]=1[N:8]=[C:47]([C:48]1[O:51][CH:52]=[CH:50][CH:49]=1)[N:10]=2

Participants

8

Reactant 7

HCID 3276844,6-Pyrimidinediamine, 2-(methylthio)-5-nitroso-HCID 18982098HCID 18982098, compoundHCID 18982108HCID 18982108, compoundHCID 18982116HCID 18982116, compoundHCID 18982131HCID 18982131, compoundHCID 18982132HCID 18982132, compoundHCID 18982133HCID 18982133, compound

Product 1

HCID 178503367HCID 178503367, compound

Procedure

The starting materials for Examples 10, 11, 12 were prepared as described in Example 5 starting from 4,6-diamino-2-methylthio-5-nitrosopyrimidine. 4,6-diamino-2-(2-phenylethyl)amino-5-nitrosopyrimidine; m/e [M+H]30 259; 4,6-diamino-2-[2-(3,4-dimethyoxyphenyl)ethyl]amino-5-nitrosopyrimidine m/e [M+H]+ 319; 4,6-diamino-2-[2-(4-methoxyphenyl)ethyl]amino-5-nitrosopyrimidine; 2-(2-phenylethyl)amino-4,5,6-triaminopyrimidine; m/e [M+H]+ 245; 2-[2-(3,4-dimethoxyphenyl)ethyl]amino-4,5,6-triaminopyrimidine; m/e [M+H]+ 305; and 2-[2-(4-methylphenyl)ethyl]amino-4,5,6-triaminopyrimidine; m/e [M+H]+ 258.

Workup

  1. customThe starting materials for Examples 10, 11, 12 were prepared

Sources & evidence

ORD record
ord-aec2f0f43fe94b7ca313a8194f65cd42
Source dataset
uspto-grants-1996_03
Patent number
US05500428

Reaction notes

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