Carbon Tetrachloride → HCID 22420762, compound

HRID 1440964Notes

Reaction equation

HRID 1440964 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:12]([O:14][CH3:15])=[O:13])[N:4]=1.C(Cl)(Cl)(Cl)[Cl:23]>>[Cl:23][C:11]([C:5]1[N:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[N:6]=1)([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:12]([O:14][CH3:15])=[O:13]

Participants

3

Reactant 2

HCID 5943Carbon TetrachlorideHCID 19973938HCID 19973938, compound

Product 1

HCID 22420762HCID 22420762, compound

Procedure

Methyl 2-(4,6-dimethoxypyrimidin-2-yl)-2-phenylacetate (2.0 g) and N-chlorosuccimimide (2.0 g) were stirred at reflux in carbon tetrachloride (25 ml) under a bright light for 18 hours. The reaction mixture was filtered and evaporated to dryness, and the residue was purified by column chromatography on silica eluting with ether:hexane (1:1), yielding the desired product (2.16 g) as a pale yellow oil.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customevaporated to dryness
  3. customthe residue was purified by column chromatography on silica eluting with ether:hexane (1:1)

Sources & evidence

ORD record
ord-727ab4899b6d480d85695f63d2e01447
Source dataset
uspto-grants-1996_03
Patent number
US05502028

Reaction notes

Loading…