Sodium Hydroxide → HCID 53968628, compound

Participants

Reaction Steps

Methyl 2-fluoro-3-methyl-2-(4,6-dimethoxypyrimidin-2yl)butanoate (1.0 g) (see Example 9 below) was dissolved in methanol (7 ml), and was treated with 5N sodium hydroxide solution (1.5 ml) at 5°-10° C. The methanol was evaporated off, and the residue was treated with water, then made acid with 5N hydrochloric acid, saturated with sodium chloride, and extracted with ether. The ethereal solution was washed with saturated sodium chloride solution and dried over magnesium sulfate. The product obtained by evaporation of the ether was triturated with pentane, yielding the desired product (0.87 g).

Provenance & Evidence