Sulfuryl chloride → HCID 57311760, compound

Participants

Reaction Steps

To a solution of 6α-trifluoromethyl-androsta-1,4-diene-3,17-dione (3.524 g, 10 mmol) in pyridine (35 ml) was added dropwise sulfurylchloride (2.699 g, 20 mmol) at about +5° C. in 20 min. The reaction mixture was stirred further 1 h at +5° C. and then poured onto water. The precipitate was filtered off and the residue purified by trituration in ethylacetate and dichloromethane. Thus almost pure title compound was obtained in about 60% yield (2.32 g).

Provenance & Evidence