反应详情

The intermediate (20 mg) from Example 4, Step 4(C) was dissolved in methanol (4 mL), followed by the addition of 10-20 mg of 5% Pd/C. Hydrogen was introduced with a balloon and the reaction mixture was stirred at room temperature for 30 min. (longer reaction time for reaction at larger scale). The reaction mixture was filtered through Celite to remove the catalyst. Solvent was evaporated in vacuo to give a crude product, which was subjected to the protocol described in Example 1, Step 1(D) to yield the title compound.

1. customlonger reaction time
2. customfor reaction at larger scale)
3. filtrationThe reaction mixture was filtered through Celite
4. customto remove the catalyst
5. customSolvent was evaporated in vacuo
6. customto give a crude product, which