反应详情

Under a nitrogen atmosphere, a stirred solution of 8.7 grams (0.015 mole) of 3-(4-chlorophenyl)-3-methyl-1-iodo-1-tributylstannylbutane and 6.5 mL (0.045 mole) of 1,8-diazabicyclo 5.4.0!undec-7-ene (DBU)in 50 mL of tetrahydrofuran was heated at reflux for about 18 hours. The reaction mixture was cooled and poured into about 225 mL of water. The mixture was then made acidic with aqueous 2N hydrochloric acid and extracted with two 150 mL portions of diethyl ether. The combined extracts were dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was subjected to column chromatography on silica gel, using 5% methylene chloride in petroleum ether as the eluant. The product-containing fractions were combined and concentrated under reduced pressure, yielding 5.3 grams of 3-(4-chlorophenyl)-3-methyl-1-tributylstannyl-1-butene. The NMR spectrum was consistent with the proposed structure.

1. temperatureat reflux for about 18 hours
2. temperatureThe reaction mixture was cooled
3. extractionmade acidic with aqueous 2N hydrochloric acid and extracted with two 150 mL portions of diethyl ether
4. dry with materialThe combined extracts were dried with magnesium sulfate
5. filtrationfiltered
6. concentrationThe filtrate was concentrated under reduced pressure to a residue
7. concentrationconcentrated under reduced pressure