Methyl morpholine oxide → HCID 11116244, compound

Participants

Reaction Conditions

Reaction Steps

To 10.2 g (65.93 mmol) of (E)-4-cyclohexyl-2-buten-1-ol dissolved in 700 mL of CH2Cl2 with 10 g crushed activated 4A molecular sieves was added 11.97 g (102.2 mmol) of N-methyl morpholine-N-oxide. This mixture was cooled to 0° C. and a catalytic amount 1.197 g (3.40 mmol) of tetrapropylammonium perruthenate was added slowly. After 18 hr the mixture was filtered through celite, concentrated in vacuo, and filtered through a plug of silica gel (6×6 cm 5% ether in hexanes) to provide the title compound as a colorless oil. Further purification by fractional distillation (bp 58°-60° C., 2 mm of Hg) afforded an oil.

Provenance & Evidence