Water → HCID 22421095, compound

Participants

Reaction Steps

To 4-(3-hydroxyprop-1-ynyl)benzaldehyde (500 mg.) in dry benzene (20 ml.) was added acetic anhydride (326 mg.) and anhydrous sodium acetate (112 mg.). The mixture was heated at reflux for 4 hours. After cooling, water (50 ml.) was added followed by ether (50 ml.). The organic layer was separated and washed with sodium carbonate solution (2×50 ml.), washed with water, dried over anhydrous magnesium sulphate and evaporated in vacuo. The product was isolated by column chromatography on silica eluting with ether:hexane; 1:1. Nuclear Magnetic Resonance (NMR) was as follows; 2.2, 3H, s; 5.0, 2H, s; 7.5, 4H, dd; 10.0, 1H, s.

Provenance & Evidence