Hydrochloric Acid → HCID 22421079, compound

Participants

Reaction Steps

Dimethyl 1-acetylcyclohexane-1,4-dicarboxylate (see Process K) (26.5 g.) was added to a solution of concentrated hydrochloric acid (290 ml.) in ethanol (140 ml.). After refluxing for 7.5 hours, the reaction mixture was poured into water and then extracted with dichloromethane. The organic phase was then washed with saturated sodium bicarbonate solution and brine. After drying over anhydrous magnesium sulphate the solvent was removed under reduced pressure to give ethyl 4-acetylcyclohexanecarboxylate as a colourless oil. This was purified by distillation (b.p 144°-148° C./14 mm Hg.).

Provenance & Evidence