HRID1441060

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NC(=O)c1ccc(-c2ccc3[nH]cc(C[C@H]4CCCN4C(=O)OCc4ccccc4)c3c2)cc1

HCID22859559

未命名化合物

PRODUCTS

生成物

结构：NC(=O)c1ccc(-c2ccc3[nH]cc(C[C@H]4CCCN4)c3c2)cc1

HCID22859575

未命名化合物

收率 83.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

3-(1-Benzyloxycarbonylpyrrolidin-2(R)-ylmethyl)-5-(4-carbamoylphenyl)-1H-indole (355 mg, 0.784 mmol) (see Preparation 41) in ethanol was reduced using catalytic hydrogenation, as described in Example 35. This gave the title compound as a white foam (210 mg). Found: C,72.33; H,6.80; N,12.35; C20H21N3O.3/4H2O requires: C,72.16; H,6.81; N,12.62%.