HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tri-o-tolylphosphine → HCID 22859567, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tri-o-tolylphosphine | HCID 80271 | — |
| Reactant | (R)-5-Bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole | HCID 11185464 | — |
| Reactant | HCID 22420947 | HCID 22420947 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 22859567 | HCID 22859567 | — |
Reaction Steps
5-Methoxycarbonyl-3-pyridyltri-n-butylstannane (see Preparation and 5-bromo-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1H-indole (see Preparation 36) were reacted together in the presence of tri-o-tolylphosphine, triethylamine and palladium (II) acetate using a procedure similar to that described in Example 1. This yielded the title compound as an oil. The product, which was impure, was used without characterisation in the preparation of Example 49.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05502065 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-2ce49afda9774ccdac883fb12d0f42ce |
| Source note | uspto-grants-1996_03 |