HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium ethoxide → HCID 22859565, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | (R)-5-Bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole | HCID 11185464 | — |
| Reactant | 4-(Diethylboranyl)pyridine | HCID 13318871 | — |
| Reactant | N-butyl-ammonium bromide | HCID 21904131 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Product | HCID 22859565 | HCID 22859565 | — |
Reaction Steps
5-Bromo-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1H-indole (see Preparation 36) and diethyl (4-pyridyl)borane (see Preparation 50) were reacted together in the presence of sodium ethoxide, n-butylammonium bromide and tetrakis(triphenylphosphine)palladium(O) using a procedure similar to that in Example 56. This gave the title compound. Found: C,75.77; H,7.16; N,13.78%; C19H21N3.1/8CH2Cl2 requires: C,76.06; H,7.09; N,13.91%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05502065 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-7853c0fe6f1e44ffb8b2a13f712edb85 |
| Source note | uspto-grants-1996_03 |