HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fmoc-Gly-OH → L-Phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fmoc-Gly-OH | HCID 93124 | — |
| Reactant | Fmoc-phenylalanine | HCID 978331 | — |
| Reactant | Fmoc-L-tryptophan | HCID 978343 | — |
| Reactant | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid | HCID 978356 | — |
| Reactant | (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid | HCID 7009636 | — |
| Reactant | 4-tert-Butyl N-((9H-Fluoren-9-ylmethoxy)carbonyl)-D-aspartate | HCID 7018816 | — |
| Product | L-Phenylalanine | HCID 6140 | — |
| Product | L-Tryptophan | HCID 6305 | — |
| Product | N-Methylphenylalanine | HCID 6951135 | — |
Reaction Steps
By following essentially the procedure of Table 2 and sequentially coupling Fmoc-MePhe-OH, Fmoc-DAsp(OtBu)-OH, Fmoc-Phe-OH, Fmoc-Trp-OH, Fmoc-Gly-OH, Fmoc-Ahx-OH and Hpa-OSu, the title compound was prepared. Amino Acid analysis following acid decomposition gave Asp 1.01 (1), Gly 0.99 (1), MePhe 1.06 (1), Ahx 1.02 (1), Trp 1.06 (1), Phe 0.94 (1), NH3 0.82. MS (FAB): m/e 931 (M-H)-.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05502164 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-cb08aa5f47424d19ac33ed09291c68ca |
| Source note | uspto-grants-1996_03 |