HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fmoc-Gly-OH → L-Phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fmoc-Gly-OH | HCID 93124 | — |
| Reactant | Fmoc-L-tryptophan | HCID 978343 | — |
| Reactant | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid | HCID 978356 | — |
| Reactant | (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid | HCID 7009636 | — |
| Reactant | N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-alpha-methyl-L-aspartic acid beta-t-butyl ester | HCID 7019716 | — |
| Product | L-Phenylalanine | HCID 6140 | — |
| Product | L-Tryptophan | HCID 6305 | — |
| Product | Caprine | HCID 21236 | — |
| Product | N-Methylphenylalanine | HCID 6951135 | — |
Reaction Steps
By following essentially the procedure of Table 2 and sequentially coupling Fmoc-MePhe-OH, Fmoc-MeAsp(OtBu)-OH, Fmoc-Ahx-OH, Fmoc-Trp-OH, Fmoc-Gly-OH, Fmoc-Ahx-OH and Hpa-OSu, the title compound was prepared. Amino Acid analysis following acid decomposition gave MeAsp 1.01 (1), Gly 1.05 (1), MePhe 0.91 (1), Ahx 2.02 (2), Trp 0.84 (1), NH3 0.82. MS (FAB): m/e 909 (M-H)-.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05502164 |
| Source dataset | uspto-grants-1996_03 |
| ORD ID | ord-0e70947c102c424092ae9d4f378d191a |
| Source note | uspto-grants-1996_03 |