HCID 178444813, compound → HCID 178434969, compound

Participants

Reaction Conditions

Reaction Steps

The intermediate (85 mg, 0.104 mmol) from Step 7(B) was dissolved in 27 mL of 1,2-dichloroethane, followed by the addition of Grubbs Catalyst 2nd Generation (6 mg, 0.007 mmol) with 1 mL of 1,2-dichloroethane. The resulting reaction mixture was stirred at 45° C. for 2 hrs. Solvent was evaporated in vacuo to give a crude product, which was purified by flash chromatography (8% EtOAc/DCM) to give two compounds, 8 mg of cis-8C (Rf 0.37) and 45 mg of trans-8C (Rf 0.26).

Provenance & Evidence