Dimethylformamide dimethyl acetal → HCID 44591764, compound

Participants

Reaction Steps

To a suspension of 2,4-dichloro-N-{[4-(3-fluoropyridin-2-yl)-1-[(1H-1,2,3-triazol-4-yl)sulfonyl]piperidin-4-yl]methyl}benzamide (0.15 g; 0.29 mmol) in toluene (5 ml) was added N,N-dimethylformamide dimethyl acetal (0.35 g; 0.4 ml; 2.92 mmol) and the mixture heated at reflux for 1 hour. The solvent was removed under vacuum and the residue azeotroped twice with toluene. The crude product was purified by preparative TLC on silica gel eluted with 3% methanol in DCM to give the title compound as the most polar isomer.(30 mg).

Provenance & Evidence