反应详情

To a stirred suspension of tert-butyl 3-cyanoazetidine-1-carboxylate (5 g; 27.43 mmol) and 2-chloro-3-fluoropyridine (5.05 g; 38.41 mmol) in toluene (100 ml) cooled in an acetone/ice bath under an atmosphere of N2, was added a solution of potassium bis(trimethylsilyl)amide (0.5M solution in toluene; 71.34 ml; 35.67 mmol) over 30 minutes keeping the internal temperature below −10° C. The reaction mixture was allowed to warm to ambient temperature, then stirred an additional 2 hours. The reaction was poured into brine (150 ml) and extracted with EtOAc (3×100 ml). The combined organic phase was washed with brine (100 ml), dried (MgSO4), filtered and evaporated to give a brown oil. The crude product was chromatographed on silica gel eluted with 5% EtOAc in DCM to give the desired product as colourless oil (2.67 g).

1. temperaturecooled in an acetone/ice bath under an atmosphere of N2
2. customthe internal temperature below −10° C
3. extractionextracted with EtOAc (3×100 ml)
4. washThe combined organic phase was washed with brine (100 ml)
5. dry with materialdried (MgSO4)
6. filtrationfiltered
7. customevaporated
8. customto give a brown oil
9. customThe crude product was chromatographed on silica gel
10. washeluted with 5% EtOAc in DCM