反应详情

Utilizing a mixture of (22Z)-9-amino-14,31-dichloro-5-methyl-25-oxa-4-thia-3,8,10,16,19-pentaazatetracyclo[24.2.2.212,15.02,6]dotriaconta-1(28),2,5,8,12,14,22,26,29,31-decaene-7,17-dione and (22E-9-amino-14,31-dichloro-5-methyl-25-oxa-4-thia-3,8,10,16,19-pentaazatetracyclo[24.2.2.212,15.02,6]-dotriaconta-1(28),2,5,8,12,14,22,26,29,31-decaene-7,17-dione (Example 8) in place of tert-butyl 9-((tert-butoxycarbonyl)amino)-14,32-dichloro-5-methyl-7,17-dioxo-26-oxa-4-thia-3,8,10,16,19-pentaazatetracyclo[25.2.2.212,15.02,6]tritriaconta-1(29),2,5,8,12,14,23,27,30,32-decaene-19-carboxylate (Example 4, Step (C)), the title compound was synthesized by analogy to Example 5.