HCID 178435150, compound → HCID 178435153, compound

HRID 14413Notes

Reaction equation

HRID 14413 reaction equation
[NH2:1][C:2]1[NH:29][CH2:28][C:27]2[CH:30]=[C:31]([Cl:32])[C:24](=[C:25]([Cl:33])[CH:26]=2)[NH:23][C:22](=[O:34])[CH2:21][NH:20][CH2:19][CH2:18][CH:17]=[CH:16][CH2:15][O:14][C:13]2[CH:35]=[CH:36][C:10](=[CH:11][CH:12]=2)[C:9]2[C:5](=[C:6]([CH3:37])[S:7][N:8]=2)[C:4](=[O:38])[N:3]=1.NC1NCC2C=C(Cl)C(=C(Cl)C=2)NC(=O)CNCCC=CCOC2C=CC(=CC=2)C2C(=C(C)SN=2)C(=O)N=1>>[NH2:1][C:2]1[NH:29][CH2:28][C:27]2[CH:30]=[C:31]([Cl:32])[C:24](=[C:25]([Cl:33])[CH:26]=2)[NH:23][C:22](=[O:34])[CH2:21][NH:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][O:14][C:13]2[CH:12]=[CH:11][C:10](=[CH:36][CH:35]=2)[C:9]2[C:5](=[C:6]([CH3:37])[S:7][N:8]=2)[C:4](=[O:38])[N:3]=1

Participants

3

Reactant 2

HCID 178435150HCID 178435150, compoundHCID 178435151HCID 178435151, compound

Product 1

HCID 178435153HCID 178435153, compound

Procedure

Utilizing a mixture of (22Z)-9-amino-14,31-dichloro-5-methyl-25-oxa-4-thia-3,8,10,16,19-pentaazatetracyclo[24.2.2.212,15.02,6]dotriaconta-1(28),2,5,8,12,14,22,26,29,31-decaene-7,17-dione and (22E-9-amino-14,31-dichloro-5-methyl-25-oxa-4-thia-3,8,10,16,19-pentaazatetracyclo[24.2.2.212,15.02,6]-dotriaconta-1(28),2,5,8,12,14,22,26,29,31-decaene-7,17-dione (Example 8) in place of tert-butyl 9-((tert-butoxycarbonyl)amino)-14,32-dichloro-5-methyl-7,17-dioxo-26-oxa-4-thia-3,8,10,16,19-pentaazatetracyclo[25.2.2.212,15.02,6]tritriaconta-1(29),2,5,8,12,14,23,27,30,32-decaene-19-carboxylate (Example 4, Step (C)), the title compound was synthesized by analogy to Example 5.

Sources & evidence

ORD record
ord-feb85dd92eee4000861c7ae362e1f3ec
Source dataset
uspto-grants-2010_06
Patent number
US07732434B2

Reaction notes

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