HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1441301Generated: October 31, 2026
Potassium Carbonate → HCID 68782591, compound
https://huagongshe.com/reaction/1441301
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 68783538 | HCID 68783538 | — |
| Reactant | HCID 87573348 | HCID 87573348 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Product | HCID 68782591 | HCID 68782591 | 160.9% |
Reaction Steps
A mixture of the compound from step C (0.42 g, 1.17 mmol), the boronic acid 5 from step B (0.47 g, 0.58 mmol), and potassium carbonate (0.16 g, 1.17 mmol) in DMF/water (5 mL/2 mL) was degassed, placed under nitrogen and was added to PdCl2(dppf) (29 mg, 0.035 mmol). The mixture was heated at 75° C. for 11 h under nitrogen, and then cooled and extracted with ethyl acetate (50 mL×2). Chromatography on silica eluting with a 20% to 70% gradient of ethyl acetate/hexane gave the title compound (0.54 g, 81%). LCMS (+APCI) m/z 579 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07655662B2 |
|---|
| Source dataset | uspto-grants-2010_02 |
|---|
| ORD ID | ord-bde0c1c689144123bd830f430cf561ce |
|---|
| Source note | uspto-grants-2010_02 |
|---|
