Glycolic Acid → HCID 68689897, compound

Participants

Reaction Steps

The title compound was prepared (38 mg, 15%), using a procedure analogous to Example 154, starting from N-{4-[(3S)-3-aminopyrrolidin-1-yl]phenyl}-5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-amine (Example 153; 220 mg, 0.556 mmol) and glycolic acid (51 mg, 0.667 mmol). NMR: 1.39 (d, 6H), 1.91-2.04 (m, 1H), 2.13-2.25 (m, 1H), 2.44 (s, 3H), 3.04-3.12 (m, 1H), 3.18-3.47 (m, 3H), 3.80 (d, 2H), 4.38-4.47 (m, 1H), 5.32 (t, 1H), 5.40-5.52 (m, 1H), 6.50 (d, 2H), 7.30 (s, 1H), 7.35 (d, 2H), 7.82 (d, 1H), 8.40 (d, 1H), 9.04 (s, 1H); m/z 454.

Provenance & Evidence