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HRID1441360

反应详情

EQUATION

反应方程式

HRID 1441360 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)Cl
HCID6367

Acetyl chloride

C2H3ClO

结构：C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2)[C@@H](C)CN1
HCID57664370

rel-(2R,5S)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

C12H17N3O2

PRODUCTS

生成物

1
结构：CC(=O)N1C[C@H](C)N(c2ccc([N+](=O)[O-])cc2)C[C@H]1C
HCID68686760

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (2S,5R)-2,5-dimethyl-1-(4-nitrophenyl)piperazine (Method 28, 8.22 g, 34.95 mmol) and acetyl chloride (4.5 ml, 62.91) by the procedure of Method 26. It was obtained as an oil which solidified on standing overnight (11.39 g, >100%, contaminated with solvent) NMR (400 MHz) 1.13 (m, 6H), 3.07 (m, 1H), 3.33 (m, 1H), 3.68 (m, 1H), 4.25 (m, 2H), 4.69 (m, 1H), 7.00 (d, 2H), 8.05 (d, 2H); m/z 278.

WORKUP

后处理

  1. customIt was obtained as an oil which