HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → N-[5-bromo-3-hydroxypyridin-2-yl]-4-methylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-Bromo-3H-oxazolo(4,5-b)pyridin-2-one | HCID 13614458 | — |
| Product | N-[5-bromo-3-hydroxypyridin-2-yl]-4-methylbenzenesulfonamide | HCID 23122883 | — |
Reaction Steps
With 4-methylbenzenesulfonyl chloride, 6-bromo-[1,3]-oxazolo[4,5-b]pyridin-2(3H)-one (described in Heterocycles, 41, 2799 (1995)) was allowed to react. Then, with an aqueous solution of sodium hydroxide, the mixture was hydrolyzed to give the title compound having the following physical data.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732442B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-9538951dfb3948ce910f81244b76c00c |
| Source note | uspto-grants-2010_06 |