Fumaric Acid → HCID 178434232, compound

Participants

Reaction Steps

The product of Example 20B (68 mg, 0.11 mmol) was treated with fumaric acid (Aldrich, 14 mg, 0.12 mmol) in EtOAc/MeOH (v.10:1, 5 mL) to provide the title compound as solid (59.1 mg, 65%). 1H NMR (MeOH-D4, 300 MHz) 1.82-2.18 (m, 3H) 2.27-2.42 (m, 1H) 2.55-2.66 (m, 4H) 3.21-3.43 (m, 5H) 3.82-3.95 (m, 1H) 5.47-5.57 (m, 1H) 6.68 (s, 2H) 7.34 (d, J=9.2 Hz, 1H) 7.60 (d, J=8.8 Hz, 1H) 8.06 (dd, J=8.8, 1.7 Hz, 1H) 8.21 (d, J=9.2 Hz, 1H) 8.32 (s, 1H) ppm. MS (DCI/NH3) m/z 336(M+H)+. Anal. Calculated for C19H21N5O.1.0 C4H4O4.0.35 H2O: C, 60.35; H, 5.66; N, 15.30. Found: C, 60.06; H, 5.40; N, 15.56.

Provenance & Evidence