HRID1441423
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
The product of Example 22A (80 mg, 0.21 mmol) was treated with fumaric acid (Aldrich, 49 mg, 0.42 mmol) in EtOAc/MeOH (v. 10:1) to give the title compound as white solid (74.8 mg, 53%). 1H NMR (MeOH-D4, 300 MHz) 1.79-2.17 (m, 3H), 2.25-2.41 (m, 1H), 2.54-2.61 (m, 1H), 2.84 (s, 6H), 3.19-3.42 (m, 5H), 3.78-3.90 (m, 1H), 4.50 (s, 2H), 5.45-5.54 (m, 1H), 6.66 (s, 5H), 7.34 (d, J=9.2 Hz, 1H), 7.54-7.63 (m, 2H), 7.84 (dd, J=8.5, 1.7 Hz, 1H), 8.17 (d, J=9.2 Hz, 1H), 8.35 (s, 1H) ppm. MS (DCI/NH3) m/z 378(M+H)+. Anal. Calculated for C22H27N5O.2.5 C4H4O4.0.5 H2O: C, 56.80; H, 5.66; N, 10.35. Found: C, 56.62; H, 5.78; N, 10.09.