Hydrochloric Acid → HCID 67070301, compound

Participants

Reaction Steps

The product of Example 34A (20 mg, 0.06 mmol) was treated with HCl (Aldrich, 4M in dioxane, 0.25 mL, 1.0 mmol) in EtOAc (3 mL) at ambient temperature for 1 hour to afford the title compound as yellow solid (20.0 mg, 92%). 1H NMR (500 MHz, CD3OD) δ 1.92-2.25 (m, 3H), 2.33-2.47 (m, 1H), 2.59-2.65 (m, 1H), 2.65-2.71 (s, 3H), 3.33-3.54 (m, 5H), 3.87-4.00 (m, 1H), 5.34-5.54 (m, 1H), 7.63 (d, J=8.5 Hz, 1H), 7.70 (d, J=8.5 Hz, 1H), 7.88 (s, 1H), 8.90 (s, 2H) ppm; MS (DCI/NH3): 327 (M+H)+. Anal. Calculated for C19H20N4O2.1.20 HCl.1.50 H2O: C, 56.39; H, 5.60; N, 13.45. Found: C, 56.05; H, 5.99; N, 13.76.

Provenance & Evidence