Hydrochloric Acid → HCID 67070017, compound

Participants

Reaction Steps

The product of Example 37A (60 mg, 0.18 mmol) was treated with HCl (Aldrich, 4M in dioxane, 0.25 mL, 1.0 mmol) in EtOAc (3 mL) at ambient temperature for 1 hour to afford the title compound as yellow solid (60.0 mg, 83%). 1H NMR (500 MHz, CD3OD) δ 1.89-2.28 (m, 3H), 2.30-2.54 (m, 1H), 2.61-2.76 (m, 1H), 3.36-3.52 (m, 5H), 3.82-3.99 (m, 1H), 5.40-5.52 (m, 1H) 7.20-7.47 (m, 2H), 7.68 (s, 1H), 8.80 (s, 2H) ppm; MS (DCI/NH3): 338 (M+H)+. Anal. Calculated for C18H18N4O3.2.00 HCl.1.50 H2O: C, 49.33; H, 5.29; N, 12.78. Found: C, 49.40; H, 5.07; N, 12.60.

Provenance & Evidence