Hydrochloric Acid → HCID 68540435, compound

Participants

Reaction Steps

The product of Example 47B (110 mg, 0.24 mmol) was treated with HCl (Aldrich, 4 M in dioxane, 0.5 mL) in iPrOH at ambient temperature overnight. The title product was obtained as a yellow solid (50 mg, yield, 53%). 1H NMR (300 MHz, CD3OD) δ ppm 1.93-2.31 (m, 3H), 2.33-2.55 (m, 1H), 2.65-2.81 (m, 1H), 3.33-3.59 (m, 5H), 3.59-3.75 (m, 1H), 5.38-5.77 (m, 1H), 6.68 (d, J=4.07 Hz, 1H), 7.43-7.45 (m, 1H), 7.65 (d, J=8.80 Hz, 1H), 7.71-7.78 (dd, J=8.40, 2.10 Hz, 1H), 8.28 (d, J=1.36 Hz, 1H), 8.86 (s, 1H) ppm; MS (DCI/NH3) m/z 355, 357 (M+H)+.

Provenance & Evidence